Catherine Bradford was born on December 11, 1858 in Taylor County, Virginia (now West Viginia). She married Isaac Monroe Spiker on June 21, 1884 in Ritchie County, West Virginia at the age of 25. She worked as housewife. Catherine died on May 21, 1919 at the age of 60 in Washburn, Ritchie, West Virginia due to a "Cancer of the Womb". She is buried at the Indian Creek Cemetery in Washburn, Ritchie, West Virginia.
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Catherine Bradford and her half-sister, Laura Cline, married brothers. Catherine married Isaac Monroe Spiker; Laura married his brother, William Forest Spiker.